Changes in tumor immunity during therapy determined by leukocyte adherence inhibition and dermal testing
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چکیده
منابع مشابه
Hemocytometer leukocyte adherence inhibition technique.
The hemocytometer leukocyte adherence inhibition technique was employed in a criss-cross experimental design with two cancer patients (melanoma and colon carcinoma) and the corresponding tumor extracts. These extracts had been repeatedly tested for specific reactivity and lyophilized before transport to the workshop. The patients' leukocytes were mixed singly with each extract in the presence o...
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The global outbreak of coronavirus disease-2019 (COVID-19) has affected most countries in the world. Our knowledge of diagnostic tests for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is evolving, and it is important to have a clear understanding of the nature of the tests and the interpretation of their findings. In this paper, the purpose is to interpret the results of two typ...
متن کاملThe need to establish whether the leukocyte adherence inhibition test is a reliable assay of tumor immunity in humans.
Lymphocytes from human cancer patients can react to tissue-type-specific antigens shared by many tumors of the same histological type and different for tumors of different types. Such reactions have been detected, for example, by using microcytotoxicity assays and leukocyte migration inhibition techniques. Work presented at this workshop indicates that the leukocyte adherence inhibition test is...
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Mechanisms of leukocyte adherence inhibition (LAI) phenomenon were investigated by utilizing Halliday's hemacytometer method. When guinea pig were immunized with dinitrophenyl conjugated bovine serum albumin (DNP BSA) with Freund's complete adjuvant, the adherence of their leukocytes to glass surface is markedly inhibited by the presence of BSA or PPD, but not by bovine gammaglobulin (BGG). Per...
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cellular immune assays in vitro (13). Purified, soluble, tumor-specific antigens are necessary reagents for the development of tissue-type-specific tumor marker assays and are also the most desirable antigens for studies that characterize the host-immune response to tumor-associ ated antigens. In view of the excellent tumor specificity and sensitivity of the micro-LAI3 assay (21, 29) as well as...
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ژورنال
عنوان ژورنال: Cancer
سال: 1978
ISSN: 0008-543X,1097-0142
DOI: 10.1002/1097-0142(197803)41:3<1034::aid-cncr2820410335>3.0.co;2-f